High Protein Diet and Huntington's Disease

High Protein Diet and Huntington's Disease

Huntington's disease (HD) is a neurodegenerative disorder caused by the huntingtin (HTT) gene with expanded CAG repeats. In addition to the apparent brain abnormalities, impairments also occur in peripheral tissues. We previously reported that mutant Huntingtin (mHTT) exists in the liver and causes urea cycle deficiency. A low protein diet (17%) restores urea cycle activity and ameliorates symp...

Applying Bioinfomatics Strategies in Huntingtons Disease Research

Huntingtin and the molecular pathogenesis of Huntingtons disease

Huntington’s disease (HD) is a late-onset neurodegenerative disorder that is caused by a CAG repeat expansion in the IT15 gene, which results in a long stretch of polyglutamine close to the amino-terminus of the HD protein huntingtin (htt). The normal function of htt, and the molecular mechanisms that contribute to the disease pathogenesis, are in the process of being elucidated. In this review...

MRI Tz Hypointensities in basal ganglia of premanifest Huntingtons disease

Changes of milk fat, crude protein, true protein, NPN and protein:fat ratio in Holstein cows fed a high concentrate diet from early to late lactation

Percentages and yields of fat, crude protein (CP), true protein (TP) and non-protein nitrogen (NPN) wereassessed in milk of four groups of Holstein cows, at early, mid and late lactation (days in milk 20-70, 71-110, 111-150 and 151-210), on a diet rich in concentrates during a hot summer. Four milk samples were taken from individual cows at 10-day intervals. Milk fat percentages were close to b...